Результаты исследования эффективности комплексной терапии, включающей топические средства Liftactiv B3 и IPL-терапию, в лечении пациентов с мелазмой

Abstract

Purpose of the study. Comparative assessment of the effectiveness of the combined protocol of IPL therapy, serum and Liftactiv B3 cream in patients with hyperpigmentation (melasma) in accordance with clinical and special research methods. Material and methods. The study included 60 patients in 2 groups. Patients in the main group and the control group received IPL therapy procedures once every 4 weeks, 3 procedures per course. In the main group, all patients used a daily alternation of serum and Liftactiv B3 cream. In the control group, patients used photoprotective cream SPF 30. Special methods included: digital dermatoscopy, mexametry. Clinical methods included: mMASI index, MELASQoL quality of life scale, GAIS scale. Results. According to the dynamics of the mMASI index at control point V5: the decrease in the main group was 87.9%, in the control group – 60.0%. The decrease in mexametry compared to the control point V1 in the main group in V5 was 90.1%, in the control group –60.1%. The decrease in the MELASQoL index at point V5 in the main group was 90.3%, in the control group – 59.9%. According to GAIS (patient), in the control group, 26.7% of patients achieved significant improvement, 73.3% –moderate improvement, in the main group, 60% of patients achieved significant improvement, 40% – moderate improvement. According to GAIS (researcher), in the control group, 33.3% of patients achieved significant improvement, 66.7% – moderate improvement, in the main group, 70% of patients achieved significant improvement, 30% – moderate improvement. Conclusions. The combined use of IPL therapy (3 procedures), serum and Liftactiv B3 cream is more effective than monotherapy with broadband pulsed light during a 12-week follow-up period. The obtained results about the lower effectiveness of IPL therapy compared to the complex method can be explained by the synergistic effect of the combination of a physiotherapeutic factor and an external drug, the wide spectrum of action of Liftactiv B3 topical agents (influence on various pathogenetic mechanisms of melasma), as well as the need to carry out a larger number of procedures for mono broadband light therapy.