Влияние демографических и антропометрических показателей на содержание антитромбина III у пациенток с тяжелой формой преэклампсии

Abstract

A natural anticoagulant antithrombin III can serve as a possible marker of severe pre-eclampsia. The concentration variability of antithrombin III is known, depending on some demographic and anthropometric patient data. Objective. To study the connection between antithrombin III levels and the values of demographic and anthropometric indicators in patients with severe pre-eclampsia and normal pregnancy. Patients and methods. In order to achieve the objective of the study, two groups of 50 pregnant women in each were formed. Indicators were evaluated using the paired comparison method. Such indicators were age, presence or absence of obesity, ationality and gestation period. Results. Studies showed that the presence of obesity in pregnant women is accompanied by a decrease in the level of antithrombin III, more pronounced in severe pre-eclampsia. The group of pregnant women with the lowest level of antithrombin III against the background of severe pre-eclampsia was also determined, depending on the nationality: among the Crimean Tatars, they were pregnant with obesity, regardless of age, and among the Slavs – pregnant women who had increased body mass index combined with older age. Conclusion. The data obtained revealed the features of the connection between anthropometric and demographic indicators of patients with severe pre-eclampsia and the level of antithrombin III, allowing the use of antithrombin III as a prognostic marker of severe pre-eclampsia. Key words: antithrombin III, marker, complications, prognosis, severe pre-eclampsia