Клінічні симптоми порушень функції печінки у вагітних із HCV-інфекцією

Abstract

Purpose - to analyze the clinical syndromes and symptoms of liver dysfunction in pregnant women with viral hepatitis C (HCV infection). Materials and methods. A prospective analysis of clinical syndromes and symptoms of liver dysfunction in pregnant women with HCV infection was conducted. Diagnosis of chronic hepatitis C (HCV) in the reactivation phase (with the presence of a positive ELISA result for anti-HCV) - in 120 pregnant women, the main group (MG). The control group (CG) consisted of 40 healthy pregnant women. According to the materials of pregnancy histories of the Kyiv Municipal Center of Reproductive and Perinatal Medicine for the period 2018-2022. Statistical processing of research results was carried out using standard programs “Microsoft Excel 5.0” and “Statistica 8.0”. Results. In the III trimester of pregnancy, pregnant women with HCV infection had significant differences in the astheno-vegetative syndrome, when compared with the healthy group, due to increased fatigue - 21 (17.5%) cases (p<0.001), sleep disturbances - 20 (16.7%) cases, drowsiness - 47 (39.2%) cases and difficulty falling asleep. Irritability was observed much more often in pregnant women with MG - 14 (11.7%) cases (p=0.033), headache in pregnant women with HCV infection was more often - 11 (9.2%) cases than in healthy pregnant women - 1 (2.5%) case, (p=0.033). Dyspepsia syndrome in the III trimester of pregnancy in MG was characterized by decreased appetite - 5 (4.2%) cases, (р=0.012), pain in the epigastrium and right hypochondrium - 21 (17.5%) cases, (р=0.001), as well as more frequent development of heartburn - 27 (22.5%) cases against 3 (7.55) cases in CG, (p<0.001). Itching of the skin was more typical for pregnant MG - 11 (10.8%) cases (p=0.009) than for healthy 1 (2.5%) cases. Skin rashes and dry skin have been reported. Conclusions. Despite the absence of specific complaints and symptoms in pregnant women with HCV infection, the frequency of asthenic syndrome, manifested by weakness and increased fatigue, irritability, as well as dyspeptic phenomena represented by nausea, vomiting, heartburn, was significantly higher than in healthy pregnant women. Specific signs of liver damage, such as subicteric sclera, pain in the liver region, tenderness on palpation, skin itching due to intrahepatic cholestasis of pregnancy, were characteristic of pregnant women with HCV infection. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was adopted by the Local Moral Committee of the institution indicated in the work. Informed consent was obtained from the women for the study. No conflict of interests was declared by the author.