Abstract
Дослідження експресії різних субодиниць еукаріотного фактора елонгації трансляції eEF1 у гліальних пухлинах головного мозку людини
Highlights
Elongation factor 1 is a multiprotein complex playing a pivotal role in the translation of genetic information in eukaryotic cell
The complex consists of four functionally different subunits: eEF1A is responsible for the delivery of correct aminoacyl-tRNA to the A- site of
The mRNA, coding for glial tissue eEF1A1 isoform, is found to be highly expressed, and no difference in the eEF1A1 mRNA level was found between normal brain and glioblastoma samples (Fig.1)
Summary
Elongation factor 1 (eEF1) is a multiprotein complex playing a pivotal role in the translation of genetic information in eukaryotic cell. Expression of eEF1A1, eEF1A2, eEF1Ba, eEF1Bb and eEF1Bg genes was analyzed by Northern blot hybridization of a panel of brain tumor and normal brain tissue RNAs. Totally 23 glioblastoma and 10 normal brain samples were investigated. No meaningful difference in the mRNA content for the eEF1A1, eEF1Ba and eEF1Bg subunits as compared to normal brain tissues was found.
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