Клініко-лабораторні кореляції помірного ожиріння та дисбалансу вітаміну D з предикторами прееклампсії

Abstract

There is a lot of evidence regarding the validity of various biomarkers as predictors of preeclampsia. However, despite the obviousness and necessity of such studies for women with obesity, such works are not numerous and their data are contradictory. Purpose - to investigate different predictors of preeclampsia in patients with moderate obesity, depending on vitamin D status. Materials and methods. A prospective controlled clinical study was conducted in which 101 pregnant women were included: the main group, consisting of women with moderate obesity (n=75), and the control group, consisting of almost non-obese pregnant women (n=26). The level of 25(OH)D in blood serum, markers of gestational endotheliopathy, blood flow in the uterine arteries of pregnant women, and markers of prenatal screening in the first trimester were studied. STATISTICA 10 software was used for statistical data processing. Results. Among the women in the main group, 85.3% had vitamin D insufficiency or deficiency in their serum. In such women in the first trimester of pregnancy, a significant increase in cases of microalbuminuria with a level of >5.0 mg albumin/mmol creatinine and a decrease in cases of endothelium-dependent vasodilatation with an index of <15.0%, a significantly higher resistance index in the uterine arteries, cases of early lateral and bilateral diastolic notch, as well as a statistically significantly lower level of β-hCG were observed. Conclusions. Moderate obesity and low vitamin D status were statistically significantly associated with predictors of preeclampsia. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.