Роль генетических факторов в вероятности развития сахарного диабета 2-го типа

Abstract

Type 2 diabetes mellitus (DM2) is the ninth leading cause of worldwide mortality. To predict likelihood of the disease and its unfavorable clinical course with developing complications, it is necessary to consider genetic and molecular factors of DM2 pathogenesis. Therefore, the aim of this review was to analyze the role that belongs to genetic factors in molecular mechanisms of DM2 development and to establish the most significant single nucleotide polymorphisms (SNP) in DM2 pathogenesis. The authors have analyzed literature sources found in such databases as CYBERLENINKA, E-library, and National Center for Biotechnology Information over the last 10 years as well as the integrated database GeneCards. By now, Genome-Wide Association Studies (GWAS) have identified about 100 genes and more than 700 polymorphisms that influence DM2 risks and its likelihood. Classifications of candidate genes with their effects and expression being limited by external and internal transcription factors are rather tentative. Literature analysis has established certain ambiguousness of the role that belongs to genetic markers in DM2 pathogenesis. It is advisable to add new genetic markers of the PPARγ, TLR4, IRS and IL-6 genes to the existing test-systems. This will increase the likelihood of detecting hereditary predisposition to diabetes mellitus according to the key molecular-genetic mechanisms of its development and ensure implementation of relevant measures aimed at preventing the disease and early identification of genetic risk groups.