Abstract
Молекулярно-імпринтовані полімери як штучні аналоги біологічних рецепторів. 2. Практичне за стосування у новітній біотехнології
Highlights
The special attention is paid to such areas of biotechnology: sensor technology, solid-phase extraction, pseudoimmunoassay, and chromatography
Molecularly-imprinted polymers (MIPs) are being widely used as a stationary phase for high-performance liquid chromatography (HPLC)
Liquid chromatography is an effective method of MIPs’ properties investigation. Their application in liquid chromatography has a number of essential drawbacks. It is broadening of chromatographic peaks associated with difficulties of mass transfer through the highly-cross-linked polymer as well as occurrence in MIPs binding sites with different affinity to the template molecule
Summary
The present review is devoted to application of molecularly imprinted polymers in modern biotechnology, i.e. sensor technology, solid-phase extraction, pseudoimmunoassay, and chromatography. Application of MIPs in analytical chemistry, biotechnology, medicine, food chemistry, and environmental monitoring attracts significant attention of analysts due to necessity of development new effective methods for sample pre-concentration and purification [44, 45]. Application of porous MIP monoliths eliminates main drawbacks of the analysis based on MIP particles (long preparation times and significant losses of the selective binding sites during preparation of the polymer).
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