전기자극의 강도와 측정전극의 간격이 감각신경신호의 파라미터에 미치는 영향 연구

Abstract

Abstract: This study was designed to investigate the effects of stimulation intensity and inter-electrode distanceon the parameters of the measured sensory nerve signal. 30 healthy subjects participated in this study. Sensory nervesignals were elicited by four different pulse amplitudes, i.e., 3, 6, 9, 12 mA, with the pulse width fixed at 500μs. Thesensory nerve signals elicited by the four different pulse amplitudes were measured by four different inter-electrodedistances (20, 30, 40, and 50 mm). We extracted four parameters (pulse amplitude, pulse width, pulse area, andlatency time from stimulation) from the sensory nerve signals. The measured pulse amplitude and pulse width wereincreased when the measuring inter-electrode distance was increased while the stimulating pulse amplitude wasfixed. The measured pulse amplitude was saturated with the stimulating pulse amplitudes of over 6 mA while mea-suring inter-electrode distance. Under the same condition, measured pulse width was increased, and sensory nervesignal was initiated early. Sensory nerve signals, specially those of pulse amplitude, were distorted by a differentialamplification method that commonly measures the human body signal. The experimental results indicate that thedifferential amplification method is required to be replaced when measuring nerve signals. Our observations sug-gested that the hyperpolarization of the action potential of the sensory nerve signal for preventing distortion couldbe used to clarify the correlation between the parameters of the sensory nerve signals and quantification of sen-sations.Key words: Sensory nerve signal, Stimulation intensity, Inter-electrode distance, Parameter