Abstract
Некроптоз эпителиоцитов кишечника и его связь с интестинальным воспалением
Highlights
Chronic inflammation in the gut has been drawing much attention of both researchers and clinicians for last decades
Numerous studies focus on the etiology and pathogenesis of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation [1]
Necroptotic cell death is characterized by immunogenic properties, which are associated with the liberation of damageassociated molecular patterns (DAMPs) from the cells, underwent necroptosis [19]
Summary
Chronic inflammation in the gut has been drawing much attention of both researchers and clinicians for last decades. Numerous studies focus on the etiology and pathogenesis of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation [1]. There are two forms of IBD: Crohn’s disease (CD) and ulcerative colitis (UC). The former is associated with transmural inflammation and affects all parts of the gut, while the latter is characterized by mucosal superficial colonic inflammation [2]. In addition to apoptosis and necrosis, the role of recently described alternative cell death modes (necroptosis, ferroptosis, and pyroptosis) in IBD is of huge interest. The aim of this paper was to review researches that focus on necroptosis of IECs and its contribution to the development and progression of intestinal inflammation
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