ДИНАМИКА КЛИНИКО-ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ПАЦИЕНТОВ В ПОСТ-КОВИДНЫЙ ПЕРИОД

Abstract

At the end of 2019, the world faced a serious problem – an outbreak in China of a new coronavirus infection caused by SARS-CoV-2. Aim: to study the dynamics of the clinical and functional state of patients, the state of humoral immunity after coronavirus infection at different time intervals. Materials and methods: The study included 153 patients hospitalized in the 10th City Clinical Hospital in Minsk with a confirmed diagnosis of coronavirus infection in the period from 12/01/2021 to 12/31/2021. Depending on the severity of the disease, patients were divided into 3 groups: severe (n = 54), moderate (n = 51), mild (n = 48). All patients underwent standard laboratory and instru-mental studies. After discharge, the patients were under dynamic observation. Af-ter 3, 6 and 9 months, the clinical and functional state was assessed, the content of IgG to SARS-CoV-2 was determined. Results: In the group with a severe course of COVID-19, subfebrile body tem-perature persisted (11.1 % of patients), saturation of 94–90 % (5.6 % of pa-tients), an increase in blood pressure by 9 months after the disease, while in groups with a moderate and mild course of the disease, the indicators normalized by the 6th month. The most pronounced humoral immune response was ob-served 3 months after the disease in the group of patients with a severe course (IgG to SARS-CoV-2 was detected in 88.9 %) compared with a moderate course (72.5 %) and mild (37.5 %). An increase in ferritin levels >330 µg/l may indicate the persistence of the humoral immune response beyond 36 weeks. Conclusion: Subfebrile body temperature, low saturation, and a statistically significant increase in blood pressure by 9 months after the illness persisted in patients who underwent severe COVID-19. At the same time, these patients showed the most pronounced immune response to SARS-CoV-2.