Abstract
Objectives The purpose of this study is to examine whether the use of Ephedrae herba and Ephedrine in obesity treatment is safe for the liver. Methods Toxicology studies and randomized controlled trials (RCTs) from systematic review (SR), meta-analysis related to Ephedrae herba or Ephedrine, which refer to liver function were collected through Pubmed and RISS databases. Results There were no findings that hepatotoxicity was induced by Ephedrae herba in the 2-week acute, 4-week subacute, and 13-week repeated administration toxicology studies. In the RCT studies of Ephedrae herba, Ephedrine, or herbal medicine including Ephedrae herba, there were no significant changes in liver function levels. Conclusions This study suggests that it is difficult to find clear evidence that Ephedrae herba and Ephedrine cause liver injury.
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