Abstract
The aim of the study was to investigate the content of fecal calprotectin in patients at different stages of chronic kidney disease (CKD). The study included 3 groups of patients: the 1st group included 80 patients with terminal renal failure (TRF) treated by hemodialysis; the 2nd group included 30 patients with S3a-5 CKD (glomerular filtration rate (GFR) 60 ml/min/1.73 m2); the 3rd group included 20 patients with CKD S1-2 (GFR 60 ml/min/1.73 m2 ), comparable by the main clinical and demographic characteristics. The level of fecal calprotectin significantly increased along with the severity of renal failure and reached maximum values in patients on dialysis. In addition, in the groups of patients with moderately severe and severe CKD the concentration of fecal calprotectin was significantly correlated with C-reactive protein (CRP) and the activity of gastrointestinal symptoms (GIS) assessed by the Gastrointestinal Symptoms Questionnaire (GSQ).
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