Сучасні аспекти застосування психофармакотерапії у хворих на поширений псоріаз

Abstract

The objective: to optimize the treatment of patients with advanced psoriasis by applying a complex method that includes psychopharmacotherapy. Materials and methods. There were 163 patients with acute psoriasis aged 18 to 74 years, of which 88 were men (53.9%) and 74 were women (46.1%). All patients underwent a comprehensive clinical and laboratory examination in accordance with the guidelines. To determine the psychoemotional state, all patients with psoriasis were subjected to a pathopsychological examination: determination of the level of reactive anxiety (RA) on the Spielberger-Hanin scale. Patients with moderate to high levels of anxiety disorders were divided into two groups. The first therapeutic group (I Group, 74 people) consisted of patients who received the anxiolytic drug mebicar against the background of traditional therapy. The therapeutic comparison group (Group II, 72 people) was formed by patients who received only traditional therapy. Results. It was found that the average RT score among all patients was (50.9 ± 0.8), which corresponded to a high level. The majority of patients (85–52.2%) had high RA levels. At the end of the course of therapy with the developed method, patients of Group I had a statistically significant decrease in the level of RA by 1.4 times and a decrease in the average score to (35.2 ± 0.4) points. But in patients of Group II, the RA level also decreased, but only by 1.1 times (p < 0.05) and the average score was significantly higher compared to the indicator in Group I by 1.3 times. Patients in Group I had an improvement in the clinical manifestations of psoriasis (PASI50) on average (10.3 ± 0.1) days of treatment. A similar result was achieved in patients of Group II only on (15.5 ± 0.2) days, which is significantly later than in Group I. Consequently, the appointment of differentiated psychopharmacotherapy contributed to an earlier regression of clinical manifestations. Conclusions. It was found that the vast majority of patients with psoriasis had a high level of RA, which should be taken into account when prescribing complex therapy. The appointment of psychopharmacotherapy contributed to the normalization of the psychoemotional state and earlier regression of clinical manifestations (the PASI50 state was achieved on (10.3 ± 0.1) days of treatment, which is 5.2 days less than in patients who received only traditional therapy).