Abstract

The study was performed on rats, which were subjected to immobilization stress (24 h). It was found that stress leads to hypertrophy of the adrenal glands, the involution of the thymus, spleen, the appearance of gastric ulcers, increased levels of cortisol and corticosterone in the blood serum. Also, an increase in 12-fold of 99mTc-pyrophosphate accumulation in the heart was found. Experiments on the isolated perfused rat heart have been shown that stress reduces the left ventricular systolic pressure and increases the diastolic pressure, but does not affect the coronary flow. The morphological study showed that stress causes segmental contractions, interstitial edema, karyopyknosis. Stress did not affect the levels of creatine kinase in the coronary flow and the blood serum. Stress did not change the ECG properties.

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