Abstract
The article describes the study of comparative efficiency of fenazid (isonicotinoilhydrazine-О,N’) ferrous dihydrate sulphate (II) and isoniazid in drug susceptible pulmonary tuberculosis patients. The high treatment efficiency namely significant improvement and improvement was observed in the patients of Group 1 – 84.1% which could be compared to the standard treatment regimen (85-7%) in Group 2. The total number of adverse reactions in the main group was confidently lower – 18.6% against 33.9%, p < 0.05. Hepatotoxic reactions with 2-3 fold increase of alaninetransferase level was registered significantly less (9.3%) in Group 1 compared to the Group treated with isoniazid.
Highlights
1s t . petersb urg research in stitu te of phthisiopulm onology, s t . petersburg, r u ss ia 2pu sh kin TB d isp en sary, s t . petersburg, r u ss ia
M unicipal TB hospital, s t. petersburg, russia The article describes the study of comparative efficiency of fenazid ferrous dihydrate sulphate (II) and isoniazid in drug susceptible pulmonary tuberculosis patients
The high treatm ent efficiency namely significant im provem ent and im provem ent was observed in the patients of Group 1 - 84.1% w hich could be compared to the standard treatm ent regim en (85.7%) in Group 2
Summary
1s t . petersb urg research in stitu te of phthisiopulm onology, s t . petersburg, r u ss ia 2pu sh kin TB d isp en sary, s t . petersburg, r u ss ia. Petersburg, russia The article describes the study of comparative efficiency of fenazid (isonicotinoilhydrazine-0,N ’) ferrous dihydrate sulphate (II) and isoniazid in drug susceptible pulmonary tuberculosis patients. Чаще диагностирован инфильтративный туберкулез легких (74; 74,7%), значительно реже - диссем инированны й (23; 23,3%), в том числе с бактериовыделением в 51,5% (51) случаев, с очаговым туберкулезом - 1 и ту беркулезным плевритом - 1 пациент.
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