Abstract
In the article the results of clinical trials are given in relation to an unconcern and efficiency of new veterinary preparation Bioton, to solution for per oral application, that contains complex biologically active foods of metabolism of mushrooms-endophytes (Cylindrocarpon Magnusianum), medical plants abstracted from a root. For the study of application of veterinary preparation Bioton it was formed 3 groups of turkeys of cross «Big-6», for 25 heads in each. The first group got preparation in a dose a 1 ml/l, the second group got in a dose 2 ml/l of water during 7day in 1, 6, 15, 21 week to fattening, the third group did not get preparation – control. The dynamics of change of body weight was determined by the individual weekly weighing. In times of carrying out the test of rejections in relation to behavior, clinical state of turkeys and diseases did not appear. Preparation Bioton, solution for per oral application, well carried by turkeys, did not cause structural changes in the investigated internals, assisted the improvement of metabolic processes, increase of body and for slaughter exit of carcass weight. Macroscopic of internal organs of turkeys that got preparation Bioton, in a dose 1–2 ml/l of water during 7 days in 1, 6, 15, 21 week of fattening, kept a characteristic anatomic structure. Weight coefficients of thymus, bursa of Fabricius, of testicles were higher in turkeys of the second group. The histological structure of the investigated internal organs specified on their active morphofunctional state in accordance with age of turkeys. The difference of indexes was more expressed in an experience group that got preparation Bioton in a dose 2 ml/l of water. Then, as for the turkeys of control group, we found out the changes of dystrophic-necrotizing character in a liver and atrophy of lymphoid tissue of organs the immune system.
Highlights
Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies named after S.Z
As for the turkeys of control group, we found out the changes of dystrophic–necrotizing character in a liver and atrophy of lymphoid tissue of organs the immune system
L.: TOV Vydavnychyj dim «SAM» (in Ukrainian)
Summary
Клінічні дослідження проводили згідно вимог Належної клінічної практики для препаратів даної фармакологічної групи (Kocjumbas et al, 2013; Doner and Szeleszczuk, 2015), у фермерському господарстві «Добробут» Пустомитівського району, Львівської області. Для вивчення безпечності та ефективності застосування нового ветеринарного препарату «Біотон», було сформовано 3 групи індиків кросу «Біг–6», по 25 голів в кожній: І група отримувала препарат в дозі 1 мл/л, ІІ група – в дозі 2 мл/л води впродовж 7 діб в 1, 6, 15, 21 тиждень відгодівлі, ІІІ група не отримувала препарат (контроль). Годівля здійснювалась комбікормом власного виробництва з додавання вітамінно– мінеральної добавки для птиці даного виду, згідно вікових категорій. Ветеринарна обробку проводили згідно норм для кросу «Біг–6» рекомендованих фірмою–поставником птиці. Після забою птиці (170 доба) проводили повний патологоанатомічний розтин по 5 голів з кожної групи із подальшим відбором матеріалу для гістологічного дослідження.
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