Abstract
The aim of the study is to identify the features of the anamnesis and laboratory characteristics of children and adolescents with platelet pathology. Materials and methods of research: the features of medical history and laboratory characteristics of children and adolescents aged 1 to 17 years with platelet pathology (thrombocytopenia and thrombocytopathy) were studied based on the analysis of 112 medical records of inpatients. Study design: retrospective, single-center, solid, non-randomized, uncontrolled. Results: when comparing parameters of the indicated nosological groups, a higher viral load was revealed in children with thrombocytopenia (level of antibodies to the herpesvirus group was statistically significantly higher in children with thrombocytopenia than with thrombocytopathy: for HSV1,2 and VEB – p<0,001, CMV – p=0,008). According to hemostasiogram, APTT was statistically significantly higher in the thrombocytopathy group (29,56±2,18 s versus 28,44±1,62 s respectively, p=0,0011), the prothrombin time was higher in thrombocytopenia (12,37±0,72 s and 12,03±0,48 s, respectively, p=0,014). The activity of von Willebrand factor is statistically significantly higher in thrombocytopenia compared with thrombocytopathy (123,78±36,35% versus 79,73±35,21%, respectively, p<0,001). A positive correlation between the relative number of platelets and leukocytes (Rs=0,40, p<0,001) has been established in the group of children with thrombocytopathy. Conclusion: the differences and dependencies identified indicate the inclusion of compensatory mechanisms of hemostasis regulation and immune protection in platelet pathology, which is more pronounced with decrease in their number.
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