Оценка микроциркуляции по данным ОКТ-А при диабетической ретинопатии

Abstract

Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) and the leading cause of blindness worldwide. The purpose of the study was to determine the characteristics of microcirculation in patients with type 2 diabetes without clinical signs of retinopathy in the fundus and at different stages of DR using the OCT-A method. As a result of the studies, an increase in the area of the FAZ with the progression of the severity of the disease, as well as a decrease in the density of parafoveal superficial and deep vessels at different stages of DR, was revealed. In the deep plexus, the decrease in vascular density occurred earlier, manifesting in patients with type 2 diabetes without DR, compared with the superficial plexus, where it began with moderate to severe NPDR and was more pronounced in PDR. Thus, a decrease in the density of the capillary network of the deep vascular plexus, which are detected even at the preclinical stages of the development of DR and increase as the disease progresses. can serve as a marker of disease severity in the early stages of diabetic retinopathy. Keywords: diabetic retinopathy, microcirculation, optical coherence tomography-angiography