ИССЛЕДОВАНИЯ ПО СОЗДАНИЮ АППЛИКАЦИОННОЙ СИСТЕМЫ ДЛЯ ЛЕЧЕНИЯ РАНЕВЫХ ПРОЦЕССОВ

Abstract

One of the promising areas of the pharmaceutical industry is the development of local drug delivery systems consisting of a biocompatible matrix and a drug. Such local delivery systems include medicinal films. Ensuring pharmacological action, accuracy of dosing, strong fixation to damaged tissues of the mucous membrane, prolongation of action are the undoubted advantages of medicinal films in comparison with traditional means of treating wound processes. The development of the technology of the drug film containing in its composition the drug cycvalone, which has a wide range of biological activity-antioxidant, anti-inflammatory, antibacterial and others - is an urgent task of pharmacy. As a result of the conducted research, the technology of a drug film with cycvalone in the form of an inclusion complex with β-cyclodextrin based on a matrix of a biodegradable polymer of sodium alginate was developed. It should be noted the availability, safety and pharmacological effectiveness of medicinal substances used in the technology of the dosage form. The inclusion of cyclodextrin in the composition of the film is due to the solubilization of the active substance molecule and an increase in the bioavailability of cycvalone during application therapy. Introduction of cycvalone in the form of complex inclusion also has a positive effect on the uniformity of distribution of the drug in the matrix and, consequently, determines the accuracy of drug dosing. After the release of the active substance, cyclodextrin is able to show detoxifying properties in the wound. The use of a modern biodegradable material as a film-forming agent provides a prolonged action of active substances, high bioavailability and enhanced therapeutic properties of the composition. The values of quality indicators of medicinal films confirming the rational selection of the composition and the optimal technology of the dosage form were experimentally established.