Нейропластичность эмбриональной ткани мозга крыс при нарушении гемодинамического обеспечения

Abstract

The investigation was aimed to study of the local cerebral blood flow, partial pressure of oxygen
 (рО2) and the character of development of local vascular reactions at embryonic neurotransplant (ENT)
 through 4, 8 и 12 months after its transplantation into the barrel field of somatic recipient’s rat brain cortex.
 In experiments, a homotopical allotransplantation 17‐day embryonic nervous tissue was conducted in the
 Wistar rats. In microareas of embryonic neurotransplant there is an uneven distribution of local cerebral
 blood flow and decrease in intensity as compared with intact somatic cortex of control rats. A 4‐month period
 after transplantation in the embryonic neuro‐transplantation there is the desired level of hemodynamic
 and oxygen supply. Dilatatory ability of micro‐vessels increases in the exercise of regulatory adaptive responses
 aimed at regulating the blood flow in nerve tissue, as evidenced by the increasing amplitude of functional
 hyperemia and magnitude of the increase of partial oxygen tension. After 8 and 12 months after transplantation,
 perfusion intensity and efficiency of ENT micro‐vessels vasodilatation are decreased. The local
 functional hyperemia is reducing, the partial pressure of oxygen increases. 4 months after transplantation
 unique properties of immature tissue persist; ENT possesses protective properties and provides neuroplastic
 effect.