Оценка информационной ценности показателей обмена у больных колоректальным раком

Abstract

Introduction. The problem of assessing the information value of indicators of the condition of patients is of a general medical nature in connection with the fundamental importance of the results of clinical examination of patients for making a diagnosis and choosing an adequate treatment tactics. The research is aimed at finding effective methods for assessing the information content of controlled indicators. Materials and methods. We examined 32 patients diagnosed with colorectal cancer. Metabolic disorders were studied on the eve of surgery and on the 14th day after surgery. To assess carbohydrate metabolism, the content of glucose (GLUCGOD) and lactate (LACT) in blood serum was studied. To assess lipid metabolism, total cholesterol (CHOL), alpha-lipoproteins (HDLC) (high-density lipoproteins), beta-lipoproteins (LDL) (low-density lipoproteins), triglycerides (TRIG) were studied. The level of the following amino acids was de-termined: methionine, cysteine, taurine, phenylalanine, tyrosine, tryptophan, glutamate, glutamine, citruline, aspartate, asparagine, arginine, ornithine, alanine, leucine, isoleucine, valine, histidine, threonine, lysine, gydroxine, serin. The calculation of correlations between the indicators is carried out. Results. In connection with the known shortcomings of the widely used method for assessing the information content of indicators by calculating the Kullback measure, a search for alternative methods that satisfy the requirements formulated in the work was carried out. The proposed method is based on a special procedure for statistical processing of the measurement results of a set of controlled indicators before and after the operation. A simple analytical relationship has been obtained that effectively detects differences in the statistical distributions of the values of the controlled indicators that appear in connection with the operation. In addition, a method for assessing the informativeness of indicators in a small sample of initial data is proposed. The method is based on identify-ing the dynamics of correlations between indicators as a result of surgery. Conclusion. Effective methods for assessing the informativeness of controlled indicators are proposed, which reveal differences in the statistical distributions of indicator values that appear in connection with the operation. Key words: Colorectal cancer; Measures for assessing the information value of indicators; A small sample of initial data.