УЛЬТРАСТРУКТУРНЫЕ ИЗМЕНЕНИЯ В ТВЕРДОЙ МОЗГОВОЙ ОБОЛОЧКЕ ПОСЛЕ КРАНИОПЛАСТИЧЕСКИХ ОПЕРАЦИЙ

Abstract

Background. Performing cranioplasty is a method of treating trepanated syndrome. Modern cranioplastic material should be biocompatible and does not cause inflammatory changes in the adjacent membranes of the brain. Aim of the research. To study ultrastructural changes in the dura mater after cranial trepanation, after plasty of the skull defect with a titanium plate "Medbiotech" and material "Superfluvis" and compare with an intact meninges. Material and methods. Rabbits underwent experimental skull trepanation (group "control"), plastic closure of the trepanation defect with titanium (group "titanium"), material "Superfluvis" (group "experience"). The "intact" group consisted of rabbits without surgery. The thickness of the dura mater and ultrastructural changes in it were studied. Results. The average thickness of the dura mater when using the "Superfluvis" material in cranioplasty was 2.74 times (p=0.005) higher than the intact one, but its thickness was 1.66 times (p=0.008) and 1.39 times (p=0.005) less in comparison with the "titan" and "control" groups, respectively. Conclusions. Cranioplasty of the trepanation defect of the rabbit skull with a material separating the dura mater from the soft tissues of the head reduces the degree of hyperplasia of fibrous tissue in this shell. The use of the "Superfluvis" material to close the defect of the rabbit skull causes less pronounced fibrosis of the TMO subject, and also contributes to greater preservation of the structure of the layer of boundary dural cells than when using a titanium plate for the same purpose.