Ингибиторы протонной помпы — это близкие или дальние родственники? (Лекция)

Abstract

Proton pump inhibitors (PPIs) are drugs that block H+-K+-ATPase on the apical membrane of the gastric parietal cells. Due to this pharmacological effect, it is possible to achieve inhibition of hydrochloric acid and its secretion formation. To date, 6 PPIs (under an international nonproprietary name) have been registered in the Russian Federation. PPIs, having proven efficacy and safety in many clinical studies, have several patterns reflected in their patient information leaflet. The attending physician should pay attention to these patterns before starting PPIs therapy. The author considers the characteristics of pharmacokinetics, pharmacodynamics of various PPIs, as well as the issues concerning efficacy and safety of use. The lecture also discusses the adverse events of PPIs, including rare ones, such as mental disorders (hallucinations), bronchospasm, subacute cutaneous lupus erythematosus. The author focuses on the metabolism peculiarities of various PPIs and the possibility of adverse drug interactions. It is especially important to consider the PPIs administration in the treatment of elderly and senile patients, patients with liver failure, during the eradication of Helicobacter pylori. KEYWORDS: proton pump inhibitors, patient information leaflet, adverse events, eradication, Helicobacter pylori. FOR CITATION: Plyusnin S.V. Are proton pump inhibitors close or distant relatives? (Lecture). Russian Medical Inquiry. 2021;5(6):398– 403 (in Russ.). DOI: 10.32364/2587-6821-2021-5-6-398-403.