Abstract
In this paper, we present data on the influence of products produced from the kelp seaweeds, such as gel from Hedophyllum bongardianum and extracts from H. bongardianum, Alaria esculenta and Fucus distichus, on the modulation of phagocytic activity of human blood neutrophils. Our experiment involved 16 volunteers who took 15 g of algal gel daily for 30 days. Before and after the experiment, their blood was taken for general analysis and also to study the level of immunomodulation after priming exposure to different concentrations (0.5, 1, 2, 5%) of algal extracts. The nonspecific resistance of the experiment participants' body was assessed by the following indicators: phagocytic activity of neutrophils, phagocytic number, absolute phagocytic index, and sum of phagocytosis. Algal extracts diluted with saline to a concentration of 2% showed the highest priming effect on the blood of examined individuals taken both before and after the consumption of algal gel per os. Low concentrations (0.25 and 0.5%) did not have a stimulating effect. When algal extracts were diluted to 5% concentration, phagocytosis was noticeably inhibited. After 30 days of consuming the algal gel, the phagocytic activity of neutrophils in all participants increased by an average of 23%, phagocytic number by 10%, and absolute phagocytic index from 2.1 to 42%. The immunostimulating effect was greatest for Alaria extracts, and the lowest for Fucus extracts. The experimental results allowed us to recommend products from Kamchatka's kelp seaweeds as adaptogenic substances.
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