Abstract
We substantiated the expediency of using synthetic analogs of the hormone melatonin in the regimen for the prevention of exacerbations and recurrences of gastric and duodenal ulcers after surgical treatment. Melatonin is used as a drug for management of desynchronosis – the mismatch of daily endogenous biorhythms during periods of increased risk of complications taking into account the patient's individual annual cycle. Computer program developed by the authors was used to calculate such periods for the first time.
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