Abstract
В статье приведен анализ литературных данных о нарушении кишечной проницаемости как одного из патогенетических факторов синдрома раздраженного кишечника. Детально рассмотрено строение плотных контактов как важного элемента нормального функционирования кишечного барьера. Рассмотрены исследования, в которых предварительно изучали экспрессию компонентов плотных контактов у больных с синдромом раздраженного кишечника. Показаны результаты собственного исследования с оценкой экспрессии окклюдина у пациентов с синдромом раздраженного кишечника. Было установлено, что экспрессия окклюдина ниже у больных с синдромом раздраженного кишечника по сравнению со здоровыми лицами.
Highlights
Irritable bowel syndrome (IBS) remains one of the most common diseases of the digestive system today
We have considered in a simplified version the normal functioning of the intestinal epithelial barrier, but the question arises about how this all is related to IBS
The use of an immunohistochemistry to evaluate the expression of occludin in the intestinal mucosa allows us to evaluate the permeability of the intestinal epithelium
Summary
Irritable bowel syndrome (IBS) remains one of the most common diseases of the digestive system today. Despite all the achievements of the last decades, the efficacy of IBS treatment remains inadequate. First of all, this is due to the fact that the modern therapy of IBS has primarily symptomatic direction. It is important to study the causes and pathogenetic factors of the onset and development of IBS with a view to their further correction, which, will significantly improve the effectiveness of the treatment of this disease. Stud ies of the last decades have confirmed that the psycho-emotional factor is sufficiently important and frequent, not the only one in the development of IBS. More and more studies are available, proving the presence of minimal inflammation in the intestinal mucosa in patients with IBS. The study of other factors for the development of this pathology continues
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