Abstract
A modern three-stage therapeutic pemphigus treatment algorithm were discussed and analyzed in the article. The main characteristics of each drug and dosage regimens were indicated. The objective. To introduce doctors-dermatovenereologists to the experience of using biological therapy in the treatment of persistent forms of pemphigus. Materials and methods. Two clinical cases of the using of the monoclonal antibodies CD20 rituximab in patients with pemphigus vulgaris and foliaceus are presented. Results. The efficiency of the using of rituximab was analyzed. It was found that monoclonal antibodies CD20 allow not only accelerate the healing of erosions in pemphigus, but also suppress the production of specific antibodies to desmoglein in the early stages of treatment, thus, reduce the corticosteroid load on the patient’s body. Conclusions. The use of modern methods of treatment of pemphigus significantly improves the prognosis of the disease. The most effective of them include the combined using of corticosteroids and monoclonal antibodies CD20.
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