Abstract
Background: The aim of this study was to investigate the potential of black rice (Oryza sativa L.) aleurone layer (BR) extract at improving the memory function of scopolamine-induced memory impaired mice.<BR>Methods and Results: BR extract (150 and 300 ㎎/㎏), scopolamine (1 ㎎/㎏), and tacrine (10 ㎎/㎏) were administered to C57BL/6 mice. We analyzed the effects of BR extract on the scopolamine-induced cholinergic system, inflammatory response, and brain damage. It was observed that the BR extract offered protection against scopolamine-induced short- and long-term memory loss, and reduced learning deficits in the behavioral task. It also improved the cholinergic system and decreased the inflammatory cytokine levels. Furthermore, the BR extract downregulated the scopolamine-induced overexpression of amyloid β-peptide and caspase-3 in the hippocampus.<BR>Conclusions: These results suggest that the BR extract may be beneficial as a dietary supplement, due to its neuroprotective effect against cognitive impairment and cholinergic deficit.
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