Abstract
In the work, activated cultures of propionic acid bacteria were found to exhibit high antimutagenic activity and adhesion properties, synthesize considerable amount of corrinoids and heme-containing enzymes. Increase of iron concentration in the medium was shown to intensify synthesis of extracellular metabolites promoting adaptation of the culture to the metal. Optimal technological parameters for isolation of casein phosphopeptides were determined. Ability of phosphopeptides to efficiently solubilize divalent iron was confirmed. Relationship between iron concentration and extent of solubilization was established. Iron chelated with casein phosphopeptides was noted to stay in divalent form for prolonged period.
Highlights
The concept of optimal nutrition implies adequate organism supply with both macro- and micronutrients, including the essential microelements, iron, as a key prerequisite for preservation of human health
The aim of the work was to study the effect of various concentrations of iron sulfate on growth and biosynthesis of extracellular metabolites by propionic acid bacteria, as well as the study on chelating properties of casein phosphopeptides
Cultures of the following propionic acid bacteria (PABs) strains were subject of the study: Propionibacterium freudenrichii subsp. shermanii AC-2503, Propionibacterium freudenrichii subsp. freudenrichii AC-2500, Propionibacterium cyclohexanicum Kusano AC-2260, and Propionibacterium cyclohexanicum Kusano AC2259, all obtained from the All-Russian Collection of Microorganisms of the Institute of Biochemistry and Physiology of Microorganisms (Moscow) and activated by a unique biotechnology method developed in the East Siberian State University of Technology and Management
Summary
The concept of optimal nutrition implies adequate organism supply with both macro- and micronutrients, including the essential microelements, iron, as a key prerequisite for preservation of human health. To preserve bioavailability of iron, role of chelating agents, which promote solubilization of minerals preserving their soluble state, is of interest. There are no data in literature on the effect of CPPs on iron solubilization. The aim of the work was to study the effect of various concentrations of iron sulfate on growth and biosynthesis of extracellular metabolites by propionic acid bacteria, as well as the study on chelating properties of casein phosphopeptides. The data indicate that casein phosphopeptides are promising chelating agents to obtain new bioavailable iron forms. FeSO4 and aqueous solution of CPPs providing for the maximum amount of solubilized iron were determined
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