Abstract
Sensorineural hearing loss is a pressing medical and social problem of modern society. A large proportion of the population is at risk of acoustic injury every day. The high incidence of acoustic trauma, coupled with insufficient diagnosis and treatment, necessitates experimental studies to identify the mechanisms of injury and to develop effective prevention and treatment. The similarities in the anatomy and physiology of the auditory analyzer of mice and humans, the relatively inexpensive keeping, and the available set of genetic tools make the mouse model extremely useful in hearing organ research. The purpose of the study was to assess changes in the auditory function of mice caused by acute acoustic trauma. The simulation of the acoustic trauma was carried out using narrow-band noise with a basic frequency of 4,000–6,000 Hz of high intensity for 4 hours. As a result, a significant increase (deterioration) in hearing thresholds was recorded in all voiced mice. On the 5th, 14th, and 28th days, there was a change in hearing in most mice. Hearing changes were uneven over time. The greatest improvement occurred from the 1st to the 5th day. With further observation, the rate of hearing recovery decreased. On the 28th day, no hearing restoration occurred in any mouse. Experimental model of acute acoustic trauma with damage parameters in this work combined with the recording of short-latency auditory induced potentials (SAEPs) can be used in further study of different types of hearing loss and development of methods of their treatment.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
