Лечение хронических эрозий роговицы путем распыления обогащенной тромбоцитами плазмы

Abstract

Purpose. To create a new way of using PRP for the treatment of the chronic corneal erosions (CCE). Material and methods. The work was performed on 24 Chinchilla rabbits (48 eyes). The study was carried out in two stages. At the first stage, a model of experimental CER was reproduced in all animals using ultraviolet radiation. At the second stage, the animals were divided into 8 groups (6 eyes in each). In group 1A, CER was treated by finely dispersed spraying of PRP over the entire surface of the cornea, further drying of the ocular surface until it dries and adhesion of the autoplasma film to the cornea in 5 layers once. In the 1B group, PRP was sprayed into 10 layers once, in the 1C group, into 15 layers once, in the 1D group, into 20 layers once, in the 1D group, into 25 layers once, and in the 1F group, into 30 layers once. Animals of the 2nd group were instilled with PRP 1 drop every 1 min. within 10 min. 1 time per day for 5 days. Animals of the 3rd group received standard conservative therapy. Conclusions. A new method of using PRP for the treatment of CCE has been created - its fine dispersion alternating with drying. The operating range for the use of PRP in the treatment of CCE by its spraying (application of at least 10, but not more than 25 layers on the corneal surface) has been determined. The application of PRP in various ways accelerates the epithelialization of CCE compared with standard conservative treatment. Spraying of PRP accelerates the epithelialization of CCE compared to its treatment with instillations. Another advantage of spraying PRP compared to instillations is the achievement of a therapeutic effect with a single application. Keywords: chronic corneal erosion, platelet-rich plasma.