Abstract
The chronobiological approach and biochemical research methods have revealed the age-related features of the ultradian rhythms of the content of total protein, albumin in rat spleen tissue normal, under the influence of natural gas and against the background of the introduction of a complex of antioxidants (vitamin E and thymalin). During the experiment, the rhythmic activity of the total protein and albumin content in rat spleen tissue during ontogenesis was compared with chronic exposure to sulfur-containing natural gas and the introduction of an antioxidant complex against intoxication. The revealed fluctuations in the content of total protein and albumin can be characterized as ultradian rhythms with periods from 20-40 to 60 minutes. The obtained experimental data indicate a decrease in the stability of spleen tissue with age and depletion of the antioxidant system of rats with aging. The materials of the article are of practical value for the development of methods for correcting the negative effects of oxidative stress in the context of intoxication.
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