Abstract
Irritable Bowel Syndrome (IBS) is a functional bowel disease in which relapsing abdominal pain is associated with bowel movements or bowel movements. Despite the numerous works devoted to the investigation of the mechanisms of IBS development, the intestinal motility in this disease has not been studied enough. The aim is to reveal the features of the motor function of the large and small intestine in irritable bowel syndrome with constipation (IBS-C) and in the case of dolichosigma. Material and methods. 84 patients with IBS-C by electromyography in comparison with a group of 25 patients with dolichosigma and a group of 35 patients with functional constipation were examined. The frequency of slow waves of the small and large intestine (patients with functional constipation) and the left parts of the colon (patients with IBS-3 and dolichosigma) by the Conan-M hardware and software complex were measured Results and discussion. IBS-C is characterized by hypomotor dyskinesia of the left divisions with pronounced spastic contractions of the smooth muscles of the circulatory layer of the gut, possibly due to the activity of stimulating serotonergic effects on the spastic activity of the circular muscle layer or inhibitory adrenergic neurons of the intermuscular (Auerbach) nerve plexus. With dolichosigma, hypomotor dyskinesia of the left parts of the colon was revealed due to stretching of the mechanoreceptors of the afferent neurons of the intramural reflex arcs.
Highlights
Irritable Bowel Syndrome (IBS)-C is characterized by hypomotor dyskinesia of the left divisions with pronounced spastic contractions of the smooth muscles of the circulatory layer of the gut, possibly due to the activity of stimulating serotonergic effects on the spastic activity of the circular muscle layer or inhibitory adrenergic neurons of the intermuscular (Auerbach) nerve plexus
4. Stasi C., Bellini M., Bassotti G. et al Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome
Summary
M. Puzikov GBUZ Moscow Clinical Research Center named after A. Отделом Ручкина Ирина Николаевна, д.м.н., ведущий научный сотрудник отдела патологии пищеварения Полева Наталья Ивановна, к.м.н., научный сотрудник отдела патологии пищеварения Пузиков Александр Михайлович, сотрудник Отдела Alla E. Department Chief Scientific Employee, MD PhD Natali I. Цель — выявить особенности моторной функции толстой и тонкой кишки при синдроме раздраженной кишки с запором (СРК-З) и при долихосигме. Аппаратно-программным комплексом «Conan-M» измеряли частоту медленных волн тонкой и толстой кишки (больным с функциональным запором) и левых отделов ободочной кишки (больным СРК-З и долихосигмой). Для СРК-З характерна гипомоторная дискинезия левых отделов с выраженными спастическими сокращениями гладких мышц циркулярного слоя кишки вследствие, возможно, активности возбуждающих серотонинергических влияний на спастическую активность циркулярного мышечного слоя или тормозных адренергических нейронов межмышечного (ауэрбаховского) нервного сплетения. При долихосигме выявлена гипомоторная дискинезия левых отделов толстой кишки вследствие растяжения механорецепторов афферентных нейронов интрамуральных рефлекторных дуг
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