Abstract
A series of experiments aimed at studying antimicrobial properties of gel experimental samples has been carried out, and their prolonged action in vivo and in vitro has been compared. The gel under study is a processed composition based on polyvinylpyrrolidone (PVP) and antimicrobial drugs; it is intended for the prevention and treatment of implant-associated infection in traumatology and orthopedics. Two methods were used to process the composition: ionizing radiation and heating. PVP treated in this way is a matrix for drug delivery to the structures of the articular cavity, which allows using antimicrobial medicines, in particular gentamicin and fosfomycin, for targeted influence on infectious agents. All gel samples, regardless of the method for their preparation, exhibited antimicrobial activity against Staphylococcus aureus, the main causative agent of postoperative infectious processes. The antimicrobial properties of the gel were long-lasting; they were observed for 14 days. No pathological changes were found in the tissues adjacent to the gel. Key words: implant-associated infection, surgery, traumatology, biofilm, polymer hydrogel, gentamicin, fosfomycin
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