Abstract
Taking into account the gut–lung microbiota axis, the new probiotic treatment methods for COVID-19 are currently being discussed. There are effective medicinal preparations of domestic manufacture in the Russian Federation, the immobilized probiotics. The study was aimed to determine the effectiveness of the mixed immobilized probiotic containing the immobilized B. bifidum and lactobacilli L. plantarum (100 million CFU per dose) or the simple immobilized probiotic containing the immobilized B. bifidum (500 million CFU per dose) in the complex therapy of patients with COVID-19. During the open-label, prospective, observational study 70 patients with confirmed diagnosis of COVID-19 received complex treatment which included the immobilized probiotics. All patients were discharged from the hospital with imporoved health status, as well as with improved instrumental and laboratory indicators: body temperature returned to normal in all patients; shortness of breath, cough, feeling of chest tightening, myalgia and headache disappeared; the patients regained sense of smell and taste; the weakness decreased or disappeared (pathognomic symptom for COVID-19). The dynamics of clinical, laboratory and instrumental indicators reflecting the course of the novel coronavirus infection demonstrates the effectiveness of the used complex therapy. The immobilized probiotics may be recommended for the complex treatment of patients with COVID-19.
Highlights
The immobilized probiotics may be recommended for the complex treatment of patients with COVID-19
The World Health Organization (WHO) on February 11, 2020 gave the disease caused by the novel coronavirus the name COVID-19 (Coronavirus Disease 2019)
Since the effectiveness of probiotics is not related to gender, and due to the features of hospitalization during the pandemic, most patients who have received treatment using the discussed scheme are males (70%)
Summary
В Российской Федерации существуют эффективные отечественные препараты — сорбированные пробиотики. Все пациенты выписаны из стационара с улучшением состояния, а также инструментальных и лабораторных показателей: у всех пациентов нормализовалась температура, исчезли одышка, кашель, ощущение заложенности в грудной клетке, миалгия, головная боль, восстановились обоняние и вкусовые ощущения, уменьшилась или исчезла слабость (характерный симптом COVID-19). Лабораторных и инструментальных показателей, отражающих течение новой коронавирусной инфекции, указывает на эффективность проводимой комплексной терапии. Сорбированные пробиотики могут быть рекомендованы к применению в комплексном лечении пациентов с COVID-19. Ключевые слова: коронавирусная инфекция, COVID-19, сорбированные пробиотики, бифидобактерии, лактобактерии Вклад авторов: Н. В. Болотов — концепция и дизайн исследования, сбор и обработка материала, написание статьи; И. В. Трухин — участие в организации работы, редактирование статьи. Under existing conditions of the fast spread of infection and limited evidence of the COVID-19 treatment, the WHO recommendations allow one to prescribe drugs off-label in accordance with the ethical standards [1]
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