Abstract

Blood samples from six 25–40 y.o. male subjects in a 5-d dry immersion (DI) experiment were analyzed for cholesterol, cholesterol of high- (HDLP), low- (LDLP) and very low density lipoproteins, triglycerides, apolipoproteins А1 (аpoА1) and apolipoproteins В (аpоВ), non-esterified (free) fatty acids (NEFA), β-hydroxibutyrate and phospholipids. Atherogenic indices were calculated, as well as the ratios of cholesterol, аpоВ/аpоА1 and cholesterol/phospholipids. No significant changes in cholesterol or lipoprotein fractions were determined. Increases in the triglyceride level and apoB/apoA1 ratio as harbingers of incipient atherogenesis showed up on the final day in DI and disappeared two days later. The process of readaptation to normal conditions is accompanied by the development of a stress reaction characterized by increased use of lipid substrates (phospholipids, β-hydroxybutyrate, NEFA) for energy synthesis.

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