Abstract
Results of studies of films and nonwoven membranes made of a copolymer of 3-hydroxybutiric and 4-hydroxybutyric acid (P(3HB/4HB)) as a models for wound dressings are presented. Structure and properties of P(3HB/4HB) product surface and mechanical properties depending on production method and ultrafine fibers orientation of nonwoven membranes obtained by electrospinning are studied. It is shown in cultures of mouse fibroblasts NIH 3T3 and diploid cells of human embryonic lines M-22 all the investigated P(3HB/4HB) samples are biocompatible, not cytotoxic in direct contact with cells and provide high adhesion and cell proliferation, as well as maintaining a high physiological activity up to 7 days. The P(3HB/4HB) film samples and the nonwoven membrane are suitable as biotransplantats and wound coverings.
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