Генетические аспекты развития ремоделирования миокарда у больных сахарным диабетом 2 типа

Elena V Koroleva,Olga G Kozlova,Alexander Khokhlov,Alfiya M Sirotkina

doi:10.14300/mnnc.2019.14110

Abstract

Генетические аспекты развития ремоделирования миокарда у больных сахарным диабетом 2 типа

Highlights

One of the prognostic criteria for the development of cardiovascular pathology in type 2 diabetes mellitus (DM) is the patient’s genetic characteristics
The presence of remodeling in patients with DM is associated with an increase in the frequency of registration of NOS3:894 gene polymorphism in the form of a combination of mutation homozygotes and heterozygotes by 27.9 %, heterozygous polymorphism of this gene is associated with the identification of an unfavorable version of left ventricular myocardial remodeling concentric hypertrophy (p=0.04)
It was found that eccentric hypertrophy was more often registered in patients with newly diagnosed diabetes vs. patients with the experience of the disease, in which concentric remodeling was more often detected; concentric hypertrophy was registered in groups with the same frequency

Summary

Introduction

One of the prognostic criteria for the development of cardiovascular pathology in type 2 diabetes mellitus (DM) is the patient’s genetic characteristics. The study involved 258 patients with type 2 DM, of which 50 were carried out genetic testing with the study of polymorphisms of genes AGT:704, AGTR1:1166, GNB3:825, NOS3:–786, NOS3. The presence of remodeling in patients with DM is associated with an increase in the frequency of registration of NOS3:894 gene polymorphism in the form of a combination of mutation homozygotes and heterozygotes by 27.9 %, heterozygous polymorphism of this gene is associated with the identification of an unfavorable version of left ventricular myocardial remodeling concentric hypertrophy (p=0.04). A tendency to an increase in the frequency of the mutation-homozygotes of the gene GNB3:825 by 17.6 % and NOS3:–786 by 26.4 %, as for the heterozygotes of the AGT:704 gene polymorphism by 22.6 % and AGTR1:1166 by 16.7 %. ESV – end systolic volume iRWT LV – index of relative wall thickness of the left ventricle iMM LV – index of myocardial mass of the left ventricle

Methods

Results

Conclusion