Abstract

Currently, the problems of udder inflammation in cows and obtaining high-quality dairy products have not lost their relevance. With a slight increase in the breeding stock, the percentage of animals with mastitis in the herd continues to be high. A technology for producing silver nanoparti-cles (2000 ppm) has been developed. Microbiological studies have shown that native Ag solutions exhibit bactericidal properties to museum strains of E.coli and S.aureus after 24 hours, and in a 1:10 dilution after 48 hours. Dilutions of the Ag solution with glycerin had significantly lower antibacte-rial properties against E.coli and S.aureus. As part of preclinical studies, it was found that a single dose (1.0 ml) of a solution of nanosilver and a proteolytic enzyme does not cause a fatal outcome in laboratory mice. The use of the drug for two weeks caused hyperchromia and anisocytosis of red blood cells in mice, without any macroscopic changes in internal organs.

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