저분자 알지네이트를 이용한 각막상피 보호용 콘텍트렌즈의 제조 및 항균성 평가

Abstract

In order to improve the wettability of contact lenses and to impart antibacterial properties against P. aeruginosa, E. coli and S. aureus a major bacterium that causes keratitis, alginate, low molecular weight as a natural polysaccharide, was added. Contact lenses were manufactured using 2-hydroxyethyl methacrylate(2-HEMA), 1-vinyl-2-pyrrolidinone(NVP) and ethylene glycol dimethacrylate(EGDMA). The addition of low molecular weight alginate salt(LMWAS) was carried out by the IPN method. The manufactured contact lenses were checked for moisture content, light transmittance, and antibacterial properties. It was confirmed that the moisture content augmented when the amount of LMWAS was increased, and the light transmittance did not change significantly. The antibacterial effect and minimum inhibitory concentration(MIC) were examined in strain such as P. aeruginosa, E. coli and S. aureus. It was confirmed that the LMWAS(Mw: 4082 Da) was indicated a minimum inhibitory concentration(MIC) of 0.10% against P. aeruginosa, E. coli and S. aureus and it was confirmed that the same antibacterial properties were exhibited even after mixing with the actual lens composition. These results suggest that LMWAS-combined contact lenes can be utilized as functional lenes to protect corneal epithelium.