Оптимізація тактики ведення вагітності при синдромі плацентарної дисфункції після грипу

Abstract

Purpose - optimize of pregnancy management tactics for placental dysfunction syndrome after influenza. Materials and methods. 80 pregnant women were selected after influenza transferred to early pregnancy: 40 women, whose pregnancies were optimized tactics (main group) and 40 women (comparison group), which were conducted according to clinical protocols of the Ministry of Health of Ukraine. Results. Optimization of conservation in such tactics is the use of pathogenetic and preventive measures, treatment and prevention measures to prevent placental insufficiency and reduce the negative effects of hyperimmune reactions (aspirin, dipyridamole, progestogens, intravenous immunoglobulin, vitamin D). The use of the recommended set of measures has a positive effect on hormonal functions of the placenta (normalization of progesterone and estradiol levels), state of immunity (reduction of NK-cytotoxicity, balance of cytokine profile), elimination of vitamin D deficiency and reduction of procoagulation potential of the hemostasis system. Conclusions. Creating favorable conditions for the development of gestation can reduce the incidence of placental insufficiency by almost 2 times to 35.0% against 62.5% other complications of pregnancy and childbirth, disorders of the fetus and newborn. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: pregnancy, influenza, feto-placental dysfunction, obstetric and perinatal complications, prophylaxis.