Таргетное воздействие цитиколина на ключевые звенья процессов повреждения нервной ткани

Abstract

The main modern approach to pharmacological correction of pathobiochemical disorders in the damage of nervous tissue is the use of drugs with pleiotropic effects: neuroreparative, neuroprotective and the ability to modulate the mechanisms of neuroplasticity. The target effect on the key links in the processes of damage to the nervous tissue from the group of neuroprotectors is citicoline, an analog of the natural endogenous mononucleotide cytidine-5-diphosphocholine. The clinical use of this drug is justified by central pharmacological effects, so citicoline is recommended as a means of choice for the treatment of cerebrovascular diseases. Mechanisms for the development of citicoline effects have not been studied sufficiently and are considered primarily in the context of its effect on the synthesis of phospholipids in neuronal membranes and the participation of choline in neurochemical processes. A promising and topical direction is the study of receptor targets in the mechanisms of neuroprotective and neuroreparative effects of this drug.