Перспектива местного применения регуляторов дофаминергической системы для снижения внутриглазного давления

Abstract

Dopaminergic system takes part in regulation of intraocular pressure (IOP) and other elements of the pathogenesis of glaucoma. Development of new drugs for the glaucoma treatment remains an actual problem in modern ophthalmology. Purpose. To estimate the perspective of topical use of dopaminergic system regulators as ocular hypotensive agents. Matherials and methods. The investigation was carried out on healthy Shinshilla rabbits and knock-out mice with γ-sinuclein gene deletion (γ-KO) that served for a model of ocular hypertension. IOP was measured before 10% dopamine instillation and every 30 minutes after it for 2 hours totally. Results. Single instillation of 10% dopamine caused a mean IOP decrease of 4-5 mm Hg after 1,5-2 hours. In γ-KO mice IOP decreased significantly on 5-6 mm Hg after 30 min and remained lower than the initial level for 2 hours. Conclusion. Single instillation of 10% dopamine cause a statistically significant decrease of IOP in healthy rabbits and γ-KO mice that initially have ocular hypertension. The ability of dopamine and D2 receptor agonists to decrease IOP denote the prospectivity of their use for the therapy of glaucoma. Key words: glaucoma, intraocular pressure, dopaminergic system, dopamine, γ-sinuclein knock-out mice.