Вивчення ролі лейоміоми матки в прогнозуванні та лікуванні генітальних пролапсів

Abstract

Uterine leiomyoma is one of the most common benign pelvic neoplasms in women. Uterine leiomyoma is diagnosed in perimenopausal or postmenopausal periods in more than 60% of cases. That is age category of women with a high frequency of genital prolapse with causes the frequent combination of these two pathologies. Purpose - to determine the role of uterine leiomyoma in the development and progression of genital prolapse. Materials and methods. A retrospective cohort study was conducted. It included 240 consecutively recruited patients, including: 117 women with prolapses of the internal genital organs, who made up the study group, and 123 women with normal pelvic anatomy - the comparison group. Analysis of life history, family, somatic, reproductive, gynecological and obstetric history, definition of anthropometric data was carried out. Statistical data processing was carried out using the SPSS 21 program. Results. According to the results of multivariate regression analysis, significant risk factors for the development of genital prolapse are: age, sedentary lifestyle, excessive physical activity, family history of genital prolapse, chronic obstructive pulmonary disease, uterine leiomyoma, number of pregnancies, spontaneous miscarriages in the early stages, number of deliveries, age of first childbirth, total number of intrauterine manipulations, perineal tears. Conclusions. Uterine leiomyoma is an independent risk factor for the development of genital prolapse (odds ratio: 5.93; 95% confidence interval: 1.77-19.91). The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.