Abstract
The effects of adaptation to periodic normobaric hypoxia (PNH) on the intensity of orthostatic reactions were studied after long-term simulated microgravity in Wistar rats. It was established that exposure of animals to PNH prior to the simulated microgravity attenuates the orthostatic hypotension and increases orthostatic tolerance after simulated microgravity. It was assumed that the decrease in the intensity of hemodynamic orthostatic responses is a result of the positive cross-adaptation that occurs due to stabilization of the central intersystem reflex mechanisms, mediated both chemo- and baroreceptor regulation implemented on the new functional level.
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