Abstract
The article presents 3 clinical cases of treatment of drug resistant tuberculosis in children and adolescents, illustrating the variants of the individual approach to treatment of tuberculosis with multiple/extensive drug resistance In order to improve treatment outcomes, bronchologic methods were used for the collection of specimens for bacteriological tests, chemotherapy regimens were adjusted in a timely manner, valve bronchial block (implantation of endobronchial valve) was used in one the patients to promote the cavity healing, the other patient underwent VATS resection of the upper lobe of the left lung due to numerous large foci As a result, it was possible to use a short course treatment in those patients
Highlights
The article presents 3 clinical cases of treatment of drug resistant tuberculosis in children and adolescents, illustrating the variants of the individual approach to treatment of tuberculosis with multiple/extensive drug resistance
In order to improve treatment outcomes, bronchologic methods were used for the collection of specimens for bacteriological tests, chemotherapy regimens were adjusted in a timely manner, valve bronchial block was used in one the patients to promote the cavity healing, the other patient underwent VATS resection of the upper lobe of the left lung due to numerous large foci
Согласно «Федеральным клиническим рекомендациям по диагностике и лечению туберкулеза органов дыхания с множественной и широкой лекарственной устойчивостью возбудителя» длительность интенсивной фазы ХТ должна составлять 8 мес. и более до получения двух последовательных отрицательных результатов посева с интервалом 1 мес., длительность фазы продолжения ХТ – не менее 12 мес
Summary
The article presents 3 clinical cases of treatment of drug resistant tuberculosis in children and adolescents, illustrating the variants of the individual approach to treatment of tuberculosis with multiple/extensive drug resistance. Ю. Персонифицированное лечение туберкулеза легких с МЛУ/ШЛУ МБТ у подростков // Туберкулёз и болезни лёгких. При микробиологическом исследовании материала БАЛ и браш-биопсии ДНК МБТ, КУМ не обнаружены, рост МБТК в системе Bactec MGIT 960 не выявлен. Инфильтративный туберкулез верхней доли левого легкого, С6 правого легкого в фазе распада и обсеменения, МБТ (+).
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