Структурний аналіз причин жіночого безпліддя у лікувальних закладах м. Харкова

Abstract

Female infertility in the modern world remains an urgent problem that requires new algorithms for diagnosis and control of treatment. According to various authors, the first place among the causes of infertility in women is ovarian and menstrual disorders and chronic endometritis (CE). The purpose of the study is to analyze the causes of infertility in women according to the medical documentation of the “Prime-test” laboratory for the period 2014–2021, with confirmation of the diagnosis of CE by the immunohistochemistry (IHC) method. Materials and methods. Data from the medical records of patients who applied to the “Prime-test” laboratory after various gynecological interventions were studied. Female infertility was found in 521 cases. A complex histological and immunohistochemical study was conducted in 100 cases of CH. Invitrogen and eBioscience primary monoclonal antibodies were used. The results. The median age of patients with infertility was 35.7 years, with a median age of 30.45 years for patients diagnosed with CE. Ovarian-menstrual disorders (52.78%) are in the first place in the structure of the causes of infertility, in the second place (27.83%) are CE, and in the third place are infertility with an unknown cause (8.64%). The rest of the reasons accounted for a small number of cases. CE was confirmed histologically and by the IHC method in 100 cases, while the most informative marker in doubtful cases was CD138. Conclusions. Chronic endometritis is an understudied disease that requires optimization of the diagnostic and prognostic panel with the selection of the most informative markers and markers that will allow the most complete study of the state of the endometrium before and after treatment.