Abstract
The article presents the review of publications devoted to personalized tuberculosis chemotherapy in children and adolescents with consideration of the specific course of the disease with the relevance to age. It is possible to reduce the duration of chemotherapy and the number of anti-tuberculosis drugs within the regimen. At the same time, the major criteria include results of microbiological tests of diagnostic specimens of the patient’s and/or index case and drug susceptibility tests in full both by express and traditional microbiological methods, microbiological and radiological monitoring, primarily in the intensive phase of chemotherapy. Generally, this personalized approach can assure high treatment efficacy.
Highlights
Представлен анализ литературы по подходу к персонифицированной химиотерапии туберкулеза у детей и подростков с учетом возрастных особенностей течения заболевания
The article presents the review of publications devoted to personalized tuberculosis chemotherapy in children and adolescents with consideration of the specific course of the disease with the relevance to age
It is possible to reduce the duration of chemotherapy and the number of anti-tuberculosis drugs within the regimen
Summary
Представлен анализ литературы по подходу к персонифицированной химиотерапии туберкулеза у детей и подростков с учетом возрастных особенностей течения заболевания. В. Обоснование концепции химиотерапии туберкулеза органов дыхания у детей и подростков // Туберкулёз и болезни лёгких. ВОЗ издала документ «WHO treatment guidelines for multidrugand rifampicin-resistant tuberculosis, 2018 update [Pre-final text]», в котором впервые рассматриваются вопросы возрастного подхода к проблеме ХТ с необходимостью выделения возрастной группы детей и подростков и указывается на возможность проведения укороченных курсов ХТ, в том числе и у этой категории пациентов.
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