Abstract
Markers of the satellite cells terminal differentiation in m. Soleus were analyzed following different periods of gravitational unloading simulated by rats' tail-suspension. Satellite cells were cultivated in vitro. Western blotting was used to determine levels of mTORc1, phospho-p70S6K, phospho-ACC, phospho-FOXO1 and phospho-FOXO3 involved in cells proliferation and differentiation. Desmin and АМРКа1 expression was determined using PCR analysis. It was shown that 7 and 14 days of tail-suspension lead to the increased intensity of satellite cells proliferation and activities of transcription factors FOXO1 and FOXO3 in rat soleus muscle.
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