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Abstract
To find out whether matrix metalloproteinases can be involved in the implementation of the antidiuretic effect of vasopressin, the effect of this hormone on the gelatinase activity of renal papillary cells in Wistar rats was studied by zymography. It was shown that the addition of the hormone to the suspension of renal papillary cells caused an increase in the gelatinase activity of proteins with a molecular weight of 52, 57 and 89 kDa. This effect was imitated by desmopressin, a vasopressin V2 receptor agonist. Vasopressin, but not desmopressin, caused an increase in the secretion of 57 and 89 kDa proteins by renal papillary cells in the incubation medium. The role of matrix metalloproteinases in vasopressin-induced increasing the water permeability of the intercellular matrix in the rat renal papilla is discussed.
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